SARS-CoV-2-Δ8 infection showed a trend of increasing IFN signaling (IFNλ3, interferon-stimulated gene [ISG15], and MX1, P values 0.4337, 0.1126, and 0.2285, respectively) as compared to WT at 3 dpi, while reducing IFN-stimulated gene levels (IFNλ3, ISG15, IFIT1, OAS1, and XAF1) at 6 dpi. This evidence concerns the gene ISG15 and infection.