Moreover, periodontitis represents a risk factor for the development of RA [103,104], as RA and periodontitis share common pathogenetic and immunological features, such as heightened inflammation, immune cell infiltration, augmented secretion of comparable cytokines and pro-inflammatory agents, reduced release of anti-inflammatory mediators, and activation of the NF-κB/RANKL signaling pathway [105]. Here, TNFSF11 is linked to periodontitis.