Multiple regression analysis, including DN B cells as a dependent variable and CD4 and CD8 as independent variables, showed that, for SLE patients, CD8 cells comprised the independent parameter associated with DN B cells; R2 = 0.277, p = 0.01; b coefficient = 0.032; CI = 0.01–0.05; p = 0.006. The gene discussed is CD4; the disease is systemic lupus erythematosus.