CASP3 and osteosarcoma: In cell studies, supplementation of aKG has demonstrated antitumoral potential in osteosarcoma cell lines (Saos-2 and HOS), inducing concentration-dependent effects [5] such as TP53 mutation-dependent antitumor effects in osteosarcoma cells and aKG-induced apoptosis via caspase 3 activity in leukemic cells [10].