In addition, using the data obtained from the three animal groups, a significant correlation was observed between the number of line crossings as being representative of anxiety-related behavior inflammatory biomarkers (IL-6, IL-1 β) and the Nrf-2-BDNF signaling pathway (Figure 7), which further confirms that CPA is a beneficial pleiotropic medicine to treat acute stress-induced anxiety-related behavior. The gene discussed is BDNF; the disease is Anxiety.