MMP2 and arthritic joint disease: In this MIA-induced arthritis animal model, treatment with the SHP-47B reduced pain (joint arthritis index, hindlimb index, and gait analysis) induced by MIA and restored damage to the meniscus cartilage, effectively reducing the levels of inflammatory cytokines TNF-α and IL-6, inflammatory factor PGE2, MMP-2, and nitric oxide (NO) as confirmed by hematological analysis.