In non-metastatic CRPC (nmCRPC) with conventional imaging modalities, PSMA-PET has been proven to detect metastatic sites [43], but it is unclear whether this subgroup can help identify who would benefit from the stratification of patients with this imaging PSMA-PET is also currently being investigated for use in the evaluation of treatment of metastatic prostate cancer, and the PSMA PET progression (PPP) criteria have been suggested [44]. This evidence concerns the gene FOLH1 and metastatic prostate carcinoma.