In a prospective comparative trial (ProPSMA) of 302 patients with high-risk localized prostate cancer prior to RP or radiation therapy, the diagnostic accuracy for lymph node or distant metastasis of 68Ga-PSMA-11 PET/CT was 27% (95% CI: 23–31) higher than CT and bone scan (92% (95% CI: 88–95) vs. 65% (95% CI: 88–95)) [30]. This evidence concerns the gene FOLH1 and prostate cancer.