Two distinct subgroups were identified: type I (37%), with TP53 and STK11/KEAP1 alterations, being similar to NSCLC, and type II (42%), similar with SCLC, which presents with the inactivation of TP53 and RB1 and also an upregulation of the immune-related pathways [9]. The gene discussed is KEAP1; the disease is non-small cell lung carcinoma.