This notion of cell-type-specific regulation of protein degradation is further underpinned by the fact that we show in this manuscript that SPOP is dispensable for cMYC degradation in our cell models, whereas it has been reported to mediate cMYC turnover in prostate and breast cancers (Geng et al., 2017; Luo et al., 2018). Here, MYC is linked to breast carcinoma.