The importance to precisely control IRF1 levels and its functional output is underpinned by the fact that aberrant IRF1 expression is linked to inflammatory syndromes, such as Behcet’s disease, arthritis, and systemic lupus erythematosus (Donn et al., 2001; Govind et al., 2014; Lee et al., 2007; Uddin et al., 2011; Zhang et al., 2015). The gene discussed is IRF1; the disease is systemic lupus erythematosus.