Notably, variations in the 3’-untranslated region (3’-UTR) of the gene encoding interleukin-18 receptor accessory protein (IL18RAP) can regulate NF-κB signalling to prevent neurotoxicity of induced pluripotent stem cell (iPSC)-derived microglia from C9orf72 ALS patients [75]. Here, IL18RAP is linked to amyotrophic lateral sclerosis.