Moreover, mutants of other RNA-binding proteins ATXN2, HNRNPA1, HNRNPA2B1, TATA-binding protein associated factor 15 (TAF15), and EWS RNA-binding protein 1 (EWSR1) have been directly associated with ALS pathology [160]. The gene discussed is HNRNPA1; the disease is amyotrophic lateral sclerosis.