In ALS patients, deficiency of the histone acetyltransferase (HAT) elongator acetyltransferase complex subunit 3 (ELP3) leads to a decrease in the transcriptional activation acetylation marks on lysine 14 of histone H3 (H3K14ac) and lysine 8 of histone H4 (H4K8ac) [241]. The gene discussed is ELP3; the disease is amyotrophic lateral sclerosis.