The autophagic-lysosomal pathway can be disrupted by ALS-linked mutants of the core components or the modifier factors that regulate autophagic induction (C9ORF72, TBK1), autophagosome formation and maturation (OPTN, SQSTM1, TBK1, UBQLN2, VCP, VAPB), and autolysosome formation (C9ORF72, VCP, CHMP2B, ALS2) [109]. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.