ALS-linked mutants of nuclear RNA-binding proteins TDP43, FUS, hnRNPA1, hnRNPA2B1, ATXN2, and matrin 3 (MATR3) form mislocalized cytoplasmic aggregates because of the irreversible interactions with their prion-like low-complexity domains [162]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.