Specifically, we demonstrated that Fer‐1 attenuated lipid peroxidation in stress‐induced PD susceptibility by inhibiting PEBP1 and ALOX15, which was recruited to the plasma membrane by PEBP1 to catalyze the oxidation of polyunsaturated fatty acids in phospholipids into their corresponding hydroperoxyl derivatives. This evidence concerns the gene ALOX15 and Parkinson disease.