In this study, leonurine was identified from TG and was able to protect dopaminergic neurons from stress and MPTP by directly interacting with ALOX15 and preventing the formation of ALOX15/PEBP1 complexes, providing insights into the therapeutic potential of ALOX15/PEBP1 for the targets of PD treatment. This evidence concerns the gene ALOX15 and Parkinson disease.