Nonetheless, while this excludes a function of CCL22 in the in vitro induction of Tregs by migDCs and CD81+migcDC1s, it does not exclude a potential function in vivo in the recruitment of Tregs to the tumor and suggests multiple mechanisms of action could be at play by which migDCs and CD81+migcDC1s induce Tregs in the tumor. The gene discussed is CD81; the disease is neoplasm.