Dendritic cells (DCs) DCs maintained low activity in normal human intestinal mucosa, however, the marker of DC activation, CD40, was significantly elevated in inflammatory active intestinal tissues of CD patients, and the expression of TLR-2 and TLR-4 was significantly upregulated (25).And DCs exhibited migration towards inflammatory tissues (26). The gene discussed is TLR2; the disease is Cowden disease.