The PCR results showed that compared with the normal group COL1A1 (1.32 ± 1.02 vs 6.33 ± 2.84), CXCL10 (1.21 ± 0.65 vs 1.82 ± 1.95), MMP2 (1.21 ± 0.78 vs 4.66 ± 2.67) and FGF2 (1.18 ± 0.75 vs 1.71 ± 1.00), the results showed that COL1A1 and MMP2 expression were both significantly upregulated in Crohn’s disease intestinal fibrosis (p< 0.01) (Figures 10E–H). The gene discussed is COL1A1; the disease is Crohn disease.