The onset of AIH pathogenesis is believed to originate with the introduction of self-antigenic peptides, such as CYP2D6 and FTCD in AIH-2 and the human SepSecS-tRNASec complex in AIH-1, to naive CD4 T-helper (Th0) lymphocytes [8]. Here, CYP2D6 is linked to autoimmune hepatitis.