In 2008, the International Autoimmune Hepatitis Group streamlined the diagnostic criteria into the following four parameters: liver histology, titers of autoantibodies (including ANA, SMA, anti-LKM1, anti-LKM3, and anti-LC1 autoantibodies), serum levels of γ-globulin or IgG, and absence of viral hepatitis [42]. Here, SMN1 is linked to autoimmune hepatitis.