ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Concentrations of adiponectin are decreased with increasing obesity and adiponectin deficiency affects wound healing in two main ways: first, adiponectin stimulates angiogenesis, so a deficiency of adiponectin means that angiogenesis is impaired; secondly, adiponectin promotes proliferation and migration of keratinocytes, thus a deficiency of adiponectin results in impaired re-epithelialization 80.