Despite PD-1/FOXP3 expression remaining independent of the IDH1 mutational status of the tumor, the significant association of high PD-1 and FOXP3 expressions with high mitotic index (P = 0.028 for PD-1) and (P = 0.018 for FOXP3) suggests that elevated PD-1 and FOXP3 expressions may be linked to the progression of glial tumors. The gene discussed is IDH1; the disease is glioma.