On the other hand, Myc inhibition was sufficient enough to promote the regression of pre-existing Ras-driven lung tumors indicating that certain neoplasms and their responsible oncogenes can display a high Myc-dependency both in vivo and in vitro (Sklar et al., 1991; Karlsson et al., 2003; Shachaf et al., 2004; Wu et al., 2007; Soucek et al., 2008; Dolezal et al., 2017). Here, MYC is linked to neoplasm.