The relevance of pathologic targets is dramatically underscored in vivo where high-level conditional Myc induction can rapidly induce aggressive tumors and the expression of unique transcriptomes whereas subsequent Myc inactivation causes complete tumor regression and transcriptomic normalization even before the tumor itself shows any objective gross or histologic response (Karlsson et al., 2003; Shachaf et al., 2004; Wu et al., 2007; Dolezal et al., 2017). The gene discussed is MYC; the disease is neoplasm.