Regardless of whether MYC is silenced genetically or pharmacologically, its inhibition in vitro is almost always associated with an immediate cessation of proliferation that usually coincides with G0/G1 arrest, although in cancer cells this may occur in other stages of the cell cycle or even in all stages simultaneously (Trumpp et al., 2001; Huang et al., 2006; Wang et al., 2008; von Bueren et al., 2009; Wang et al., 2015; Scognamiglio et al., 2016; Wang et al., 2022b). Here, MYC is linked to cancer.