TNFSF10 and cardiovascular disorder: While the impact of TRAIL and its receptors in regulating inflammation has not been investigated in the context of the heart, alterations in TRAIL and OPG in PBLs from patients with dilated cardiomyopathy (Schoppet et al., 2005) and TRAIL on PBMCs after myocardial infarction (Nakajima et al., 2003) suggests that immune cells may be an important source of TRAIL in cardiovascular disease.