In general, increases in infiltrating CD8+ T cells have been associated with longer OS (36), and consistent with that, we found the high-risk group showed more pronounced immunosuppressive features: with higher levels of Macrophages_M0, Macrophages_M1, Macrophages_M2 and lower levels of T_cells_CD4_memory_activated, T_cells_CD8, etc. Besides, the high-risk group had more abundant expression of ECM remodeling-related genes, and higher stromal and immune scores, suggesting that there is a relationship between ECM remodeling and tumor immunity that cannot be ignored. The gene discussed is CD8A; the disease is neoplasm.