The present meta-analysis demonstrates that the C allele of the rs17782313 polymorphism near MC4R is associated with a higher level of BMI, WC or GLU, but not with blood lipids, which is in agreement with the previous findings that the C allele of the rs17782313 variant is strongly correlated with an elevated risk of obesity and T2DM (87–89), but weakly with CVD (90). This evidence concerns the gene MC4R and obesity disorder.