The present meta-analysis demonstrates that the C allele of the rs17782313 polymorphism near MC4R is associated with a higher level of BMI, WC or GLU, but not with blood lipids, which is in agreement with the previous findings that the C allele of the rs17782313 variant is strongly correlated with an elevated risk of obesity and T2DM (87–89), but weakly with CVD (90). This evidence concerns the gene MC4R and type 2 diabetes mellitus.