PPARGC1A and obesity due to melanocortin 4 receptor deficiency: In addition, we found that the PGC1α rs8192678 polymorphism is associated with glucometabolic disorder indexes in some specific populations such as East and West Asians, Europeans, and overweight/obesity and T2DM patients although this variant is not correlated with the indexes of obesity, dyslipidemia and glucometabolic disorder in the pooled meta-analyses in the overall population.