The outlier studies were identified and excluded, but there were still no significant correlations between the rs8192678 polymorphism and all of these indexes in the whole population, which indicates that the associations of the rs8192678 polymorphism with obesity, diabetes and dyslipidemia are weak, although PGC1α works as an activator of PPARγ, an important modulator of glucose and lipid metabolism (7). The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.