Five SNPs (rs2980854 in/near TRIB1, rs429358 in/near APOE, rs10401969 in/near SUGP1, rs738409 in/near PNPLA3, rs5764430 in/near SAMM50) were chosen as IVs for NAFLD (Supplementary Table 1). Here, SUGP1 is linked to metabolic dysfunction-associated steatotic liver disease.