Our findings suggest that HMGCR inhibitors may increase BMI from a genetic perspective (1OR, 1.261 per SD reduction in LDL-C; 95% CI, 1.192–1.333; P = 5.44E-16), and that an elevated BMI is detrimental to sepsis development (OR, 1.208; 95% CI, 1.061–1.377; P = 0.004). Here, HMGCR is linked to Sepsis.