FOS and osteoarthritis: JunB proto-oncogene, AP-1 transcription factor subunit (JUNB) is a member for AP-1 complex, has been identified as the cell proliferation inhibitor and senescence inducer (50), which involves in the regulation of oral squamous cell carcinoma (51) and osteoarthritis (52), etc. However, the molecular functions for these ten hub genes identified by our study in aortic valve were still unclear.