Dyspnoea in sarcoidosis patients was associated with rs1049550 near ANXA11 (p = 0.006; OR = 1.36) and rs3024505 near IL10 (p = 0.007; OR = 0.66) in the Serbian cohort, rs12035082 at 1q24.3 (p = 0.0098; OR = 2.28) and rs4342 near ACE (p = 0.008; OR = 0.43) in the Central German cohort, and rs7517847 near IL23R (p = 0.003; OR = 3.32) and rs2279015 near SLC11A1 (p = 0.0095; OR = 0.4) in the North German cohort. Here, ACE is linked to sarcoidosis.