Both spinocerebellar ataxia type 37 and the suite of adult familial myoclonic epilepsies (FAMEs 1, 2, 3, 4, 6, 7) have non-reference expansions associated with disease.41‐47 Interestingly, both diseases have the same reference motif (ATTTT) and expanded pathogenic motif (ATTTC) within their respective genes; DAB1 and SAMD12, STARD7, MARCH6, YEATS2, TNRC6A and RAPGEF2. Here, RAPGEF2 is linked to spinocerebellar ataxia type 37.