In comparison, the phase II NIMBUS trial evaluating nivolumab and ipilimumab in patients with metastatic HER2-negative breast cancer with high TMB showed partial response in 4 of 30 (13%) patients, although patients with higher TMB (14 Mut/Mb or higher) seemed to have better response rates (60%; ref. 36). The gene discussed is ERBB2; the disease is breast carcinoma.