TARDBP and brain disorder: In consonance with the fact that AD is not only a brain disorder but also presents several peripheral and systemic abnormalities (Wojsiat et al., 2015; Esteras et al., 2016), we recently reported alterations in TDP-43 homeostasis, including increased TDP-43 phosphorylation, truncation and cytoplasmic accumulation in immortalised lymphocytes derived from AD patients.