In particular, we reported the ability of CK1, CDC-7 and TTBK1 inhibitors to restore TDP-43 homeostasis in lymphoblasts derived from ALS and FTLD-TDP patients (Alquezar et al., 2016; Martinez-Gonzalez et al., 2020; Nozal et al., 2022). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.