TARDBP and amyotrophic lateral sclerosis: Among them, the small heterocyclic compounds named IGS2.7 and VNG1.47 have shown to reduce tau and TDP-43 phosphorylation in neuroblastoma cell cultures and to promote the recovery of TDP-43 homeostasis (decrease of hyperphosphorylation and increase in nuclear localisation) in a human cell based model of ALS (Salado et al., 2014; Martinez-Gonzalez et al., 2020; Nozal et al., 2022).