On the basis of recent findings pointing out to an additional pathogenic role of TDP-43 in AD, either by itself or by interacting with β-amyloid plaques and neurofibrillary tangles formation (Meneses et al., 2021), TDP-43 can be considered as novel therapeutic target for AD disease with comorbid TDP-43 pathology (Latimer and Liachko, 2021). This evidence concerns the gene TARDBP and Alzheimer disease.