Decades of research have shed light on the neuropathological changes happening in the AD brain, and its complex etiology (Long & Holtzman, 2019), characterized by sex differences in several aspects of the disease, including its onset and progression, and the effects of APOE*4 genotype, the strongest common genetic risk factor for LOAD (Nebel et al., 2018). Here, APOE is linked to Alzheimer disease.