Emerging evidence shows that the chronic inflammatory microenvironment induced by hyperglycaemia activates the NLRP3 inflammasome and promotes the production of inflammatory factors, leading to the inhibition of proliferation and differentiation of osteoblasts; however, the silencing of Nlrp3 or inhibition of Caspase1 in osteoblasts could restore their ability to proliferate, differentiate and protect against bone mineralization deficiency in DM mice.23, 24, 25. This evidence concerns the gene NLRP3 and Hyperglycemia.