The possible explanations are that (1) the stiffness of liver metastatic lesions was associated with collagen concentration, which could accelerate the proliferation of pancreatic cancer cells at the liver metastatic lesion, consequently leading to elevated liver metastasis size [24, 25], and (2) the stiffness of peripheral liver tissue could affect epithelial-mesenchymal transition and phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) signaling in liver metastasis, which consequently promoted the growth of liver metastatic lesions [1, 9, 24, 26]. Here, AKT1 is linked to pancreatic neoplasm.