AKT1 and neoplasm: The possible explanations are that (1) relative EM was correlated with increased liver metastasis volume (abovementioned), which led to declined PFS among patients; (2) increased relative EM indicated abnormal PI3K/AKT pathway and collagen concentration in liver metastasis, which could not only regulate drug resistance but also modulate antitumor immune microenvironment via enrichment of tumor-associated fibroblasts, consequently affecting PFS among patients [24, 26, 30–32].