To further explore whether complications associated to T2DM affected the circulating levels of PCSK9, an ANCOVA test, followed by Tukey’s post-hoc comparisons, was computed after adjustment for age, sex, HbA1c, and the presence of previous MACE, atherosclerotic vascular disease, nephropathy, neuropathy and retinopathy. This evidence concerns the gene PCSK9 and retinal disorder.