PCSK9 levels above the cut-off were associated, at the univariate level, with all-cause mortality only in males, whereas the correlation was lost after adjusting for age, hypertension, therapy with statins or with vitamin K antagonists, smoking status, disease (T2DM) duration, HbA1c, BMI, hs-CRP, non-HDL-C, and eGFR. The gene discussed is PCSK9; the disease is type 2 diabetes mellitus.