A post hoc analysis of the DIABHYCAR (Non-insulin Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events and Ramipril) cohort and SURDIAGENE (Survie, Diabète de type 2 et Genétique) cohort showed that the predictivity of CV events captured by PCSK9 depended on the individuals’ CV risk. The gene discussed is PCSK9; the disease is hypertensive disorder.