At health facilities in Lesotho and SA, we conducted the TB TRIAGE + ACCURACY study in adult presumptive TB cases to determine the diagnostic accuracy of two potential TB triage tests, namely CAD (CAD4TB v7, Delft, the Netherlands) and C-reactive protein (CRP; Alere Afinion, USA) to be used in a second large-scale collaborative study on novel TB case detection strategies [16]. This evidence concerns the gene CRP and tuberculosis.