Comparing PD and HC, the sensitivity and specificity were 76.4% and 77.4% (AUC = 0.8266, 95% CI 0.7708–0.8824) for GLT-1+/SYN211+ EVs and 67% and 84% (AUC = 0.785, 95% CI 0.7229–0.8470) for GLT-1+/MJFR14+ EVs (Fig. 7f), respectively. This evidence concerns the gene SLC1A2 and Parkinson disease.