Comparing PD and MSA, the sensitivity and specificity were 75.5% and 66% (AUC = 0.7303, 95% CI 0.6360–0.8246) for GLT-1+/SYN211+ EVs and 81.1% and 66% (AUC = 0.7132, 95% CI 0.6122–0.8142) for GLT-1+/MJFR14+ EVs (Fig. 7g), respectively. The gene discussed is SLC1A2; the disease is multiple system atrophy.