Since IL-10 signaling pathway was up-regulated in overall monocytes at MC (Additional file 2: Table S9), we next analyzed the expressions of ribonuclease A family member 2 (RNASE2) which can induce IL-10 secretion from monocytes and thus augment the age-associated B cells expansion in systemic lupus erythematosus [40]. The gene discussed is IL10; the disease is systemic lupus erythematosus.