MLH1 and colorectal carcinoma: BRAFV600E mutations of CRC are mostly characterized by high levels of CpG island methylator phenotype (CIMP) of the gene promoter, mainly caused by mismatch repair gene MLH-1 promoter methylation and microsatellite instability (MSI) as a result of gene silencing, which is considered an early event in the SSAD-carcinoma transformation [1].