CHD8 and colorectal carcinoma: In BRAF-mutated human CRC cell lines and tumors, MAFG is bound to the promoters of MLH1 and other CIMP genes and recruits a corepressor complex that includes its heterodimeric partner BACH1, the chromatin remodeling factor CHD8, and the DNA methyltransferase DNMT3B, resulting in hypermethylation and transcriptional silencing [14].