Furthermore, we corroborated the specific modulation of IL20R by BMAL1 and CLOCK transcription factors in SUP-T1 cell line, which showed higher level of IL20R in the cell surface than RPMI-8402 cells by flow cytometry analysis (Fig. 4E and S8), confirming that the circadian clock machinery promotes IL20R expression in human T-ALL cells. Here, CLOCK is linked to acute lymphoblastic leukemia.