Furthermore, we carried out co-immunoprecipitation experiments (co-IP) between BMAL1 and CLOCK protein to validate the physical interaction between both transcription factors (Fig. S1) and to corroborate the evidence that likewise non transformed cells, in T-ALL cells these two transcription factors regulate transcription as a heterodimer, as would be expected for cells with an intact circadian mechanism [42]. Here, CLOCK is linked to acute lymphoblastic leukemia.