The important role of the alteration of the biological clock in inducing reduction of the proliferative capacity of T-ALL cells was then confirmed with experiments carried out in a murine model, which showed longer survival of immunodeficient recipient mice after transplantation of leukemia T-cells obtained from patient-derived xenografts (PDXs) silenced for BMAL1 or CLOCK. This evidence concerns the gene CLOCK and acute lymphoblastic leukemia.