Additionally, gene expression data, integrated with Chromatin Immunoprecipitation Sequencing (ChIP-Seq) profiles of genetically modified leukemic cells, revealed that the circadian clock circuitry directly promoted the expression of genes, such IL20RB that encodes the β-subunit of Interleukin 20 (IL20) receptor, crucially involved in JAK/STAT signaling, making the T-ALL cells more responsive to IL20. The gene discussed is CLOCK; the disease is acute lymphoblastic leukemia.