2) A population-based database from the UK Biobank found that patients with depression were more likely to have elevated levels of C-reactive protein (CRP), indicating low-grade inflammation; however, this relationship was no longer statistically significant after adjusting for smoking and BMI, suggesting that the presumed genetic contribution to increased inflammation in depression may be regulated by eating and smoking habits rather than a genetic predisposition [15]. This evidence concerns the gene CRP and depressive disorder.