Based on the results of this study supporting previous evidence of DSC1 role in breast cancer metastasis we conclude that DSC1 could participate in breast tumor progression by co-expression with genes involved in cell proliferation in the early stage of the disease, and support the formation of secondary tumors via physical interactions of DSC1 protein with proteins maintaining cellular adhesion in the later stage of the disease. The gene discussed is DSC1; the disease is breast cancer.