Therefore, CD4 and STAT4 were considered to be hub genes of sepsis, and 6 lncRNAs (LINC00265, LINC00893, NDUFA6-AS1, NOP14-AS1, PRKCQ-AS1 and ZNF674-AS1) that regulated the two genes abovementioned based on ceRNA theory were identified as potential key biomarkers of sepsis. The gene discussed is NDUFA6; the disease is Sepsis.