In conclusion, we identified 6 lncRNAs (LINC00265, LINC00893, NDUFA6-AS1, NOP14-AS1, PRKCQ-AS1 and ZNF674-AS1) related to the immune pathogenesis of sepsis and LINC00265 was strongly correlated with the proportion of M2 macrophages. This evidence concerns the gene PRKCQ and Sepsis.