The sepsis groups generally stored a higher proportion of B cells memory (P = 0.0015), plasma cells (P = 0.0011), T cells gamma delta (P < 0.0001), monocytes (P < 0.0001), mast cell activated (P < 0.001), while the proportions of B cells naive (P < 0.0001), CD8+ T cells (P < 0.001), naive CD4+ T cells (P < 0.0001), memory resting CD4+ T cells (P < 0.0001), memory activated CD4+ T cells (P < 0.001), NK cells resting (P < 0.0001), macrophages M0, macrophages M2 (P < 0.0001) and neutrophils (P < 0.0001) were relatively lower. The gene discussed is CD8A; the disease is Sepsis.