CD40LG and Autoimmunity: While female carriers of CD40L mutations may be considered as donors for their affected family members, female carriers of XL-CGD should not be used as donors for patients with XL-CGD due to their propensity to develop autoimmunity and the risk of poor phagocyte function from mixed donor chimerism compounded with the dynamic nature of %DHR + over time [4, 29].