Foxj1 regulates ciliogenesis (Stubbs et al. 2008; Abdi et al. 2018) and is required to maintain the multiciliated phenotype of ependymal cells (Abdi et al. 2018). Ependymal motile cilia dysfunction impairs normal CSF circulation and causes hydrocephalus, although the exact mechanism by which this occurs is unclear (Kumar et al. 2021; Olstad et al. 2019). The gene discussed is FOXJ1; the disease is Hydrocephalus.