The expression of some of these epigenetic effectors, such as DNMT1, SIRT1, SIRT3, PHF2, and ZBTB33, has been previously described to change in NAFL and NASH, confirming the robustness of our findings [18, 32, 79, 86]. This evidence concerns the gene ZBTB33 and metabolic dysfunction-associated steatohepatitis.