Among them, we found HAT1, which codes for a histone acetyl- and succinyltransferase recently reported to be induced in HCC with protumorigenic consequences [114], and SMYD2, a histone methyltransferase also induced in HCCs with poor prognosis and just described to be critical for the development of experimental steatosis in mice [107, 113]. The gene discussed is PRDM9; the disease is hepatocellular carcinoma.