Several hub-hub TFs were also identified including STAT1, STAT2, STAT3, STAT5A, STAT5B, STAT646, NFKB1, NFKB2129, and IRF133, as well as a hub-hub lncRNA including CDC42SE1130, which had essential immunoregulatory roles in mastitis immunity. Here, STAT5B is linked to mastitis.