KCNS3 and Parkinson disease: Interestingly, the element R_L1_160, which previously showed to be associated with the highest number of PD progression markers (Fig. 2), affected 527 transcripts, with no transcripts regulated in cis. When looking specifically on the transcripts affected by R_L1_160, it can be highlighted that this element affects expression of previously identified novel PD risk loci, GBF1 and KCNS3 (Fig. 5b, Supplementary Data 2).