While there was an association with survival for CD8EM/C1 and CD8PEX using an univariate analysis (Fig. 4b), in a more robust multivariate analysis that also considered age at diagnosis, CD3E expression (as a marker for T cell infiltration that has been associated with survival40), menopausal state, and Nottingham Prognostic Index (NPI; which reflects the size, number of involved lymph nodes, and grade of the tumor), no association was found (Fig. 4c). The gene discussed is CD3E; the disease is neoplasm.