Subsequent assays demonstrated that RepSox induced TET2 shuttling from the nucleus to the cytosol in SW480 cells, which was accompanied by reduced TET2-dependent global DNA demethylation, impaired activation of the RORA-SPARC axis and accelerated growth of cancer cells; TGFβ exerted the opposite effects in SW620 cells (Supplementary Figure S5D-I & Table S6). This evidence concerns the gene SPARC and cancer.