To further undermine the roles of TET2 nuclear localization in different stages of tumour progression, these samples were divided into two groups based on TNM staging: as indicated in Fig. 1D, E, patients without lymph node metastasis were classified into N0, and patients with node metastasis were classified into N1-2. Here, TET2 is linked to metastatic malignant neoplasm in the lymph nodes.