To further study the role of TET2-mediated DNA demethylation activity in CRC, the catalytic domain of TET2 (Tet2CD) was exogenously expressed in 6 immortalized CRC cell lines, 12 primary cell lines established from freshly resected CRC and 8 immortalized cell lines established from other solid cancers (Supplementary Table S3). The gene discussed is TET2; the disease is colorectal carcinoma.