IFNA1 and autoimmune disease: Thus, in addition to the impaired immune response (affecting IFN-mediated immunity) and the generation of anti-type I IFN autoantibodies that drive the age-dependent severity of COVID-1918,51,53,61, patients with life-threatening SARS-CoV-2 infections also present with an age-dependent increase of multiple autoantibodies associated with classic autoimmune diseases that correlate with disease severity.