Of note, the support vector machine (SVM) classification, which is a powerful machine learning approach with maximization (support) of separating margin (vector)48,49, based on the levels of anti-cardiolipin (Fig. 6a) or anti-platelet glycoprotein (Fig. 6c) in relation to age, confirmed the importance of these autoantibodies as suitable classifiers of severe COVID-19 when compared to healthy controls. The gene discussed is ART4; the disease is COVID-19.