Therefore, Pax5+/−;Myd88+/− B-ALLs exhibited a gene expression pattern similar to human B-ALLs, and the gene expression profiles of Pax5+/−;Myd88+/− and Pax5+/− B-ALLs did not show major differences between them or when compared with gene expression profiles derived from blast cells from patients with B-ALL (Supplementary Fig. S15 and Supplementary Data 6), indicating that Myd88 is not significantly contributing to the leukemic gene expression profile of infection-driven B-ALL. This evidence concerns the gene PAX5 and infection.