Cluster 2 had the highest expression and diversity of M1 and M2 macrophage markers, in particular the general macrophage marker CD68, anti-tumor markers CD169, HLA-DR, STING, and CD38, and pro-tumor markers CD163, CD204, and CD206, and immune checkpoint molecules PD-1 and PD-L1. The gene discussed is SIGLEC1; the disease is neoplasm.