We next performed transcriptome sequencing for eWAT tissue from mice xenografted with MDA-MB-231 cells (231/Ctrl) and tumour-free control mice, and identified that hypoxia-inducible factor-1 (HIF1) and hypoxia metagene pathway were both upregulated in adipose tissue from 231/Ctrl mice (Fig. 2a). The gene discussed is HIF1A; the disease is neoplasm.