Besides, obesity drives changes in the levels of hormones such as leptin, adiponectin and ghrelin, which all have an immunomodulatory function, it remains critically important to determine whether and how circulating miR-204 intersects these metabolic, hormonal and immunologic regulations simultaneously during white adipose tissue browning and cancer-associated cachexia. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.