UCP1 and neoplasm: Histological and immunohistochemical analyses of adipose tissues showed clear signs of browning in iWAT and eWAT of LLC/Ctrl and C26/Ctrl rather than C26/miR-204 KO and LLC/miR-204 KO tumour-bearing mice, with reduced adipocyte size, a multilocular lipid droplet phenotype, and increased HIF1A, UCP1 protein abundance (Fig. 7o–q and Supplementary Fig. 7o–q).